PK Nichtkompartimentanalyse
AUC · Cmax · Tmax · t½ · CL/F · Vz/F
PK Nichtkompartimentanalyse
AUC · Cmax · Tmax · t½ · CL/F · Vz/F
Lokale Berechnung in diesem BrowserSpaltenreihenfolge: Zeit_h, Konzentration
Bearbeitbare Tabelle
| time_h | concentration | |
|---|---|---|
CSV / TSV einfügen
Analyseergebnis
Abbildungseinstellungen
Data requirements
Mindestens 2 Zeitpunkte mit nichtnegativen numerischen Konzentrationen eingeben.
Zeit_h, KonzentrationReview before reporting
Nur für Forschungszwecke. Mit Rohdaten und Analyseplan validieren.
Check raw observations, excluded rows, model assumptions and study-specific acceptance criteria before using the result.
Transparent analysis
Inputs are processed locally in your browser. Review the calculation policy, limitations and verification approach before reporting a result.
Read the methodology →EVIDENCE & REVIEW
A result you can audit.
Reviewed 12 August 2026AUC and terminal-phase calculation review complete
Implementation check
The workflow sorts concentration-time observations, applies linear trapezoids and exposes terminal regression fit before deriving half-life, AUC extrapolation, apparent clearance and volume.
Interpretation boundary
NCA results depend on sampling coverage, BQL rules, dose and route definitions, terminal-point selection and the suitability of log-linear extrapolation. Confirmatory work requires the approved analysis environment.
Method references
M13A Bioequivalence for Immediate-Release Solid Oral Dosage FormsU.S. FDA / ICHNoncompartmental PK parameters, terminal-phase estimation and AUC reporting context.
REFERENCE VALIDATION CASE
Linear trapezoid exposure
(10+5)/2 × 1 + (5+2.5)/2 × 1.
Inputs
- Time: 0, 1, 2 h
- Concentration: 10, 5, 2.5
- Linear trapezoids
Expected result
- Cmax = 10
- Tmax = 0 h
- AUC₀–last = 11.25 concentration·h
Scope: Terminal regression and extrapolated parameters need adequate later samples.
Review and correction history
12 August 2026 · Internal implementation review
AUC and terminal-phase calculation review complete. Formula behavior, unit handling, limitations and linked references were checked internally.
Independent reviewer: Not yet published. A name, relevant qualification, date and exact scope will appear here only after a real review is completed.
Source-informed and internally checked; independent scientific or regulatory validation is not claimed. Research use only.